Minimal. The cause of MGD is not bacterial; therefore antibiotics have a limited role. Doxycycline and Minocycline are often used in low doses, because they have an anti-inflammatory effect to oil glands (and are often used by dermatologists to treat acne and rosacea.) When we use oral Doxycycline or Minocycline, or a topical antibiotic of the same class, Azasite (topical azithromycin) we are using the anti-inflammatory effects of these medications, and not their antibiotic principles.